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In order to set Wildfire not to send to the American Global Wildfire.

In PAN OS Device > Setup > WildFire and edit value to

If you want less security because there is a requirements that no data is uploaded to the cloud.

Change the WildFire File type submission to exclude possible data

In Objects > WildFire Analysis

Clone default profile to a new one where you select all filetype except PDF and Office

In Traps Console

In Security Profiles > <your profile>

Under Examine Office Files with Macros

Upload Office files with macros for cloud analysis change to disabled

Another article related to this here